Phenotypes Associated with This Genotype

Genotype
MGI:5462248

hm1

• Allelic Composition: Ccl2^tm1Lex/Ccl2^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired macrophage chemotaxis ( J:191510 )

N • mice exhibit impaired recruitment of macrophages from mice homozygous for Ccr2^tm1Mae compared recruitment of wild-type cells

N • obese mice impaired recruitment of macrophages from lean wild-type mice compared with obese wild-type mice

immune system

impaired macrophage chemotaxis ( J:191510 )

N • mice exhibit impaired recruitment of macrophages from mice homozygous for Ccr2^tm1Mae compared recruitment of wild-type cells

N • obese mice impaired recruitment of macrophages from lean wild-type mice compared with obese wild-type mice

hematopoietic system

impaired macrophage chemotaxis ( J:191510 )

N • mice exhibit impaired recruitment of macrophages from mice homozygous for Ccr2^tm1Mae compared recruitment of wild-type cells

N • obese mice impaired recruitment of macrophages from lean wild-type mice compared with obese wild-type mice