Phenotypes Associated with This Genotype

Genotype
MGI:5462253

• Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk; Traf3ip2^tm1Sbn/Traf3ip2⁺
• Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:191090 )

• only 7.7% of mutants are still alive at 12 months of age

premature death ( J:191090 )

• only 7.7% of mutants are still alive at 12 months of age

renal/urinary system

kidney inflammation ( J:191090 )

• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

immune system

abnormal neutrophil morphology ( J:191090 )

• neutrophil extracellular traps are seen in the kidneys

increased neutrophil cell number ( J:191090 )

• increase in numbers of neutrophils and monocytic cells in perfused kidneys

increased myeloid dendritic cell number ( J:191090 )

• increase in CD11b+CD11c+ myeloid dendritic cells in spleens

increased plasmacytoid dendritic cell number ( J:191090 )

• increase in CD11c+B220+ plasmacytoid dendritic cells in spleens

increased plasma cell number ( J:191090 )

increased monocyte cell number ( J:191090 )

• increase in CD11b+CD11c- monocytic cells in spleens

• increase in numbers of monocytic cells in perfused kidneys

abnormal T cell morphology ( J:191090 )

• expansion of IFN-gamma producing cells, mainly T cells, in spleens

increased double-negative T cell number ( J:191090 )

• increase in numbers of double negative T cells in the kidneys

increased memory T cell number ( J:191090 )

• increase in numbers of T effector-memory cells (CD4+CD62L-CD44+)

increased single-positive T cell number ( J:191090 )

• increase in numbers of CD4+ T cells, and to a lesser degree, CD8+ T cells, in the kidneys

increased spleen germinal center number ( J:191090 )

• form spontaneous germinal centers

increased IgG level ( J:191090 )

• total serum IgG is increased and IgG deposition in the kidneys

increased susceptibility to systemic lupus erythematosus ( J:191090 )

• develop fatal lupus

increased autoantibody level ( J:191090 )

• presence of anti-nRNP (ribonucleoprotein) antibodies

increased anti-nuclear antigen antibody level ( J:191090 )

increased anti-double stranded DNA antibody level ( J:191090 )

• presence of double-stranded DNA IgG antibodies

kidney inflammation ( J:191090 )

• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

hematopoietic system

abnormal neutrophil morphology ( J:191090 )

• neutrophil extracellular traps are seen in the kidneys

increased neutrophil cell number ( J:191090 )

• increase in numbers of neutrophils and monocytic cells in perfused kidneys

increased myeloid dendritic cell number ( J:191090 )

• increase in CD11b+CD11c+ myeloid dendritic cells in spleens

increased plasmacytoid dendritic cell number ( J:191090 )

• increase in CD11c+B220+ plasmacytoid dendritic cells in spleens

increased plasma cell number ( J:191090 )

increased monocyte cell number ( J:191090 )

• increase in CD11b+CD11c- monocytic cells in spleens

• increase in numbers of monocytic cells in perfused kidneys

abnormal T cell morphology ( J:191090 )

• expansion of IFN-gamma producing cells, mainly T cells, in spleens

increased double-negative T cell number ( J:191090 )

• increase in numbers of double negative T cells in the kidneys

increased memory T cell number ( J:191090 )

• increase in numbers of T effector-memory cells (CD4+CD62L-CD44+)

increased single-positive T cell number ( J:191090 )

• increase in numbers of CD4+ T cells, and to a lesser degree, CD8+ T cells, in the kidneys

increased spleen germinal center number ( J:191090 )

• form spontaneous germinal centers

increased IgG level ( J:191090 )

• total serum IgG is increased and IgG deposition in the kidneys

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:191090