Analysis Tools
nervous system
|
• dense amyloid beta plaques in the cortex and hippocampus, but not in the adrenal medulla
|
|
• amperometric recordings from chromaffin cells stimulated with a 10 second 70 mM potassium pulse indicate that the quantity of catecholamines released during the initiation of the fusion pore is 50% smaller in mutants than in controls
• chromaffin cells exhibit smaller quantal size and faster kinetics of single exocytotic events (45% lower spike half-width, 60% smaller quantal size, 50% lower decay time) and spike feet show 60% smaller quantal size
• mutants, however, exhibit normal innervation by splanchnic cholinergic nerve terminals of chromaffin cells
|
homeostasis/metabolism
|
• dense amyloid beta plaques in the cortex and hippocampus, but not in the adrenal medulla
|
|
• chromaffin cells release 50% less catecholamine (mean quantal content released per vesicle is halved) in response to a 10 second 70 mM potassium pulse
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:191088 | ||
