Phenotypes Associated with This Genotype

Genotype
MGI:5463438

• Allelic Composition: Tg(Thy1-APPArc)M8Cagr/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:168288 )

N • mutants exhibit normal motor activity, exploratory behavior, and vertical activity in the open-field test at all ages tested

abnormal spatial learning ( J:168288 )

♀ • in the Barnes maze, mutant females exhibit longer latency to find the target hole during the acquisition phase and the reversal learning phase compared to wild-type females, however no differences are seen between mutant and wild-type males, indicating impaired spatial learning and memory in 15 month old females

abnormal long-term spatial reference memory ( J:168288 )

♀ • in the Barnes maze, mutant females exhibit longer latency to find the target hole during the reversal learning phase compared to wild-type females, indicating impaired long-term learning and memory

abnormal spatial working memory ( J:168288 )

• in a delayed alternation test, mutants show a longer latency to find the escape platform at 15 months of age compared to wild-type mice, indicating a minor impairment in working memory

nervous system

amyloid beta deposits ( J:168288 )

• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively

• amyloid beta deposition is seen around vessel walls and in the parenchyma

• females exhibit higher levels of amyloid beta deposits than males

homeostasis/metabolism

amyloid beta deposits ( J:168288 )

• amyloid beta plaques are evident in the subiculum and thalamus at 7 months and 18 months of age, respectively

• amyloid beta deposition is seen around vessel walls and in the parenchyma

• females exhibit higher levels of amyloid beta deposits than males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:168288