Analysis Tools
mortality/aging
|
• some mice from hydrocephalus at a median age of 50 days
|
behavior/neurological
| N |
• mice exhibit normal anxiety-associated behavior, fear conditioning, conditioned taste aversion, spatial memory and short-term and long-term memory
|
|
• mice exhibit decreased spontaneous alteration in a Y-maze compared with wild-type mice
|
|
• reduced exploration of objects
|
|
• mice exhibit increased spontaneous tics compared with wild-type mice
|
 |
• in male, but not female, mice treated with methylphenidate
|
|
• male and female mice exhibit reduced anogenital exploration compared with wild-type mice
• female mice exhibit increased social evasion compared with wild-type mice
• female mice exhibit reduced nonanogenital exploration and approach and follow behavior compared with wild-type mice
• however, contact behavior is normal
|
nervous system
|
• periventricular edema
|
hydrocephaly
(
J:192388
)
|
• enlarged white matter tract, most prominent in the corpus callosum with enlargement in the alveus and external capsule
|
|
• longer spines in both basal and apical dendrites
|
 |
• in female mice at high intensity
|
homeostasis/metabolism
|
|
• in male mice
|
|
• periventricular edema
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:192388 | |
