Phenotypes Associated with This Genotype

Genotype
MGI:5466506

• Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi}
• Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:191129 )

N • normal survival

nervous system

increased neuron apoptosis ( J:191129 )

• in the striatum at 6 months

decreased brain weight ( J:191129 )

• from 3 to 12 months

abnormal corpus callosum morphology ( J:191129 )

• reduced volume at 3 and 6 months

abnormal globus pallidus morphology ( J:191129 )

• reduced volume at 6 months

decreased striatum size ( J:191129 )

• progressive reduction in volume from 3 to 12 months

small thalamus ( J:191129 )

• reduced volume at 3 and 6 months

abnormal cerebral cortex morphology ( J:191129 )

• progressive reduction in volume from 3 to 12 months

abnormal cerebellum morphology ( J:191129 )

• reduced weight from 3 to 12 months

decreased neuron number ( J:191129 )

• in the striatum at 6 months

behavior/neurological

abnormal motor learning ( J:191129 )

• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice

abnormal motor coordination/balance ( J:191129 )

• at 2 months, mice exhibit reduced climbing compared with wild-type mice

• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice

• however, mice exhibit normal performance on an accelerating rotarod and motivation to climb is normal

decreased locomotor activity ( J:191129 )

• from 3 to 12 months

integument

alopecia ( J:191129 )

• around eyes

sparse hair ( J:191129 )

• hypotrichosis

decreased hair follicle number ( J:191129 )

• reduced density at P7

growth/size/body

decreased body weight ( J:191129 )

• at 12 months

cellular

increased neuron apoptosis ( J:191129 )

• in the striatum at 6 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:191129