Phenotypes Associated with This Genotype

Genotype
MGI:5467397

hm1

• Allelic Composition: Atf5^tm1Mrgr/Atf5^tm1Mrgr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Absence of milk spot in Atf5^tm1Mrgr/Atf5^tm1Mrgr neonates

mortality/aging

neonatal lethality, incomplete penetrance ( J:191236 )

• mice that fail to thrive die between P0 and P6

• 11 of 14 mice die within the first 48 hours after birth

postnatal lethality, incomplete penetrance ( J:191236 )

• mice that fail to thrive die between P0 and P6

• 11 of 14 mice die within the first 48 hours after birth

taste/olfaction

abnormal olfactory epithelium morphology ( J:191236 )

• contains a large number of apoptotic cells

• however, cell proliferation is normal

abnormal olfactory sensory neuron morphology ( J:191236 )

• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons

growth/size/body

abnormal olfactory epithelium morphology ( J:191236 )

• contains a large number of apoptotic cells

• however, cell proliferation is normal

abnormal olfactory sensory neuron morphology ( J:191236 )

• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons

decreased body weight ( J:191236 )

• in surviving mice throughout 10 weeks after birth

behavior/neurological

absent gastric milk in neonates ( J:191236 )

• in some mice

nervous system

abnormal olfactory sensory neuron morphology ( J:191236 )

• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons

craniofacial

abnormal olfactory epithelium morphology ( J:191236 )

• contains a large number of apoptotic cells

• however, cell proliferation is normal

abnormal olfactory sensory neuron morphology ( J:191236 )

• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons

respiratory system

abnormal olfactory epithelium morphology ( J:191236 )

• contains a large number of apoptotic cells

• however, cell proliferation is normal

abnormal olfactory sensory neuron morphology ( J:191236 )

• loss of olfactory marker protein (Omp) staining indicates a dramatic loss of mature olfactory sensory neurons