Phenotypes Associated with This Genotype

Genotype
MGI:5468673

• Allelic Composition: Trp63^tm1Cmis/Trp63⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:191121 )

integument

abnormal epidermal layer morphology ( J:191121 )

• compromised desmosomes in the epidermis

blistering ( J:191121 )

abnormal keratinocyte physiology ( J:191121 )

• defects in cell-cell adhesion

• however, defects are alleviated by EGFR inhibition

craniofacial

cleft palate ( J:191121 )

digestive/alimentary system

cleft palate ( J:191121 )

growth/size/body

cleft palate ( J:191121 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome		DOID:0090119	OMIM:106260	J:191121