Phenotypes Associated with This Genotype

Genotype
MGI:5469591

• Allelic Composition: Pik3ca^tm1Gne/Pik3ca⁺; Tg(MMTV-cre)1Mam/0
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:193377 )

♂N • male mice do not develop tumors in the mammary gland or seminal vesicles

increased mammary gland tumor incidence ( J:193377 )

♀ • thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition

♀ • however, treatment with PI3K inhibitor inhibits tumor growth

integument

abnormal branching of the mammary ductal tree ( J:193377 )

♀ • precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks

♀ • feathery, hyper-branched ductal tree by 50 weeks

increased mammary gland tumor incidence ( J:193377 )

♀ • thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition

♀ • however, treatment with PI3K inhibitor inhibits tumor growth

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:193377 )

♀ • precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks

♀ • feathery, hyper-branched ductal tree by 50 weeks

increased mammary gland tumor incidence ( J:193377 )

♀ • thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition

♀ • however, treatment with PI3K inhibitor inhibits tumor growth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:193377