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Phenotypes Associated with This Genotype
Genotype
MGI:5471480
Allelic
Composition
Muc2eey/Muc2eey
Genetic
Background
C57BL/6-Muc2eey
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muc2eey mutation (1 available); any Muc2 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Endoplasmic reticulum stress in the intestinal epithelium of Muc2wnn/Muc2wnn and Muc2eey/Muc2eey mice

mortality/aging
• at 1 year, some mice die or are euthanized due to rectal prolapse or debility

digestive/alimentary system
• fewer goblet cells in the small and large intestines due to increased apoptosis
• in distal large intestine
• increased in distal large intestine
• in DSS-treated mice
• increased crypt length in the cecum and distal large intestine with increased intestinal proliferation and apoptosis
• progressive increase in proximal and distal colon thickness and weight from 6 to 18 weeks
• however, colon length is not shortened
• in some mice
• in DSS-treated mice with early fecal occult blood
• in DSS-treated mice

immune system
• in DSS-treated mice with early fecal occult blood
• in DSS-treated mice
• 5-fold increase in leukocytes in the mesenteric lymph node leukocytes in untreated mice
• from distal colon explants
• from distal colon explants
• from distal colon explants
• from mesenteric lymph nodes stimulated with PMA and ionomycin

cellular
• fewer goblet cells in the small and large intestines due to increased apoptosis
• distended cells with membranous vacuolar material in the large intestine
• goblet cells possess dilated rough endoplasmic reticulum
• swollen mitochondria with disrupted cristae in the large intestine
• swollen mitochondria with disrupted cristae in the large intestine
• in distal large intestine
• increased in distal large intestine
• aberrant mucin assembly triggers an endoplasmic reticulum stress response and unfolded protein response activation

endocrine/exocrine glands
• increased crypt length in the cecum and distal large intestine with increased intestinal proliferation and apoptosis

hematopoietic system
• 5-fold increase in leukocytes in the mesenteric lymph node leukocytes in untreated mice

neoplasm
N
• unlike Muc2tm1Avel, mice do not develop spontaneous intestinal tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
inflammatory bowel disease DOID:0050589 OMIM:PS266600
J:194148


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory