Phenotypes Associated with This Genotype

Genotype
MGI:5473719

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-CTGF)#Swu/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung vasculature morphology ( J:171488 )

• pups nursing on dams administered doxycycline from P1 to P14 exhibit decreased capillary formation in alveolar septa

impaired lung alveolus development ( J:171488 )

• pups nursing on dams administered doxycycline from P1 to P14 exhibit disrupted alveolarization, showing a 27% and 31% decrease in the mean alveolar airspace area and mean cord length, respectively

• pups nursing on dams administered doxycycline from P1 to P14 exhibit disorganized elastic fiber deposition on alveolar surfaces and in septa

abnormal pulmonary interalveolar septum morphology ( J:171488 )

• pups nursing on dams administered doxycycline from P1 to P14 exhibit a 34% decrease in secondary septa

• marker analysis indicates that pups nursing on dams administered doxycycline from P1 to P14 exhibit increased myofibroblast differentiation in alveolar septa

• pups nursing on dams administered doxycycline from P1 to P14 exhibit a 48% increase in the proliferating cell index in alveolar septa

• pups nursing on dams administered doxycycline from P1 to P14 exhibit decreased capillary formation in alveolar septa

pulmonary fibrosis ( J:171488 )

• pups nursing on dams administered doxycycline from P1 to P14 exhibit thickening in the peribronchial/peribronchiolar and perivascular regions of the lungs and increased collagen deposition in these regions, indicating fibrosis

cardiovascular system

abnormal lung vasculature morphology ( J:171488 )

• pups nursing on dams administered doxycycline from P1 to P14 exhibit decreased capillary formation in alveolar septa

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lower respiratory tract disease		DOID:0050161		J:171488