mortality/aging
• only 20% of mice born alive survive beyond 100 days
|
• only 20% of mice born alive survive beyond 100 days
|
• recovered at a lower than expected Mendelian frequency
|
digestive/alimentary system
• enterocytes expressing cre have enlarged endosomes
• marked vacuolation of enterocytes in the ileum
• decrease in actin at the apical surface and ectopic localization of DPP4 and IAP
|
• sparse in number
|
• short
|
• overt fibrosis of the muscularis mucosa
|
• lymphocyte infiltration is prominent in both the mucosa and submucosa
|
homeostasis/metabolism
• decrease in circulating choline esterase levels
|
growth/size/body
• at 5 weeks of age, average weight is about 60% of the mean littermate control body weight
|
behavior/neurological
integument
immune system
• lymphocyte infiltration is prominent in both the mucosa and submucosa
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Crohn's disease | DOID:8778 | J:193689 |