Phenotypes Associated with This Genotype

Genotype
MGI:5475286

• Allelic Composition: Gclc^{tm1c(EUCOMM)Wtsi}/Gclc^{tm1c(EUCOMM)Wtsi}; Tg(Cryaa-cre)10Mlr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0051_3_D07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cataracts in Gclc^{tm1c(EUCOMM)Wtsi}/Gclc^{tm1c(EUCOMM)Wtsi} Tg(Cryaa-cre)10Mlr/0 mice

vision/eye

cataract ( J:194778 )

• in some mice starting at 3 months

• mature cataracts in half of mice by 4 months

nuclear cataract ( J:194778 )

• small at 4 months

• severe at 9 months

cellular

oxidative stress ( J:194778 )

• strong increase in reactive oxygen species production as determined by GSSG/GSH ratio

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:194778