Phenotypes Associated with This Genotype

Genotype
MGI:5478551

hm1

• Allelic Composition: Bub1^tm3.1Jvd/Bub1^tm3.1Jvd
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Seminiferous tubule diameter is reduced in Bub1^tm3.1Jvd/Bub1^tm3.1Jvd testis

reproductive system

oligozoospermia ( J:195237 )

♂ • 3.5-fold reduction of spermatozoa in the cauda epididymis

small seminiferous tubules ( J:195237 )

♂

small testis ( J:195237 )

♂

decreased testis weight ( J:195237 )

♂

decreased litter size ( J:195237 )

♂ • from male mice

reduced male fertility ( J:195237 )

♂

cellular

oligozoospermia ( J:195237 )

♂ • 3.5-fold reduction of spermatozoa in the cauda epididymis

aneuploidy ( J:195237 )

• chromosome misalignment resulting in aneuploidy in mouse embryonic fibroblasts

• in the spleen, lung and liver of DMBA-treated mice

• in primary and secondary spermatocytes

abnormal cell cycle checkpoint function ( J:195237 )

• in colcemid and taxol treated mouse embryonic fibroblasts

• not worsened by treatment with ZM447439 (aurora B kinase inhibitor)

chromosomal instability ( J:195237 )

• chromosome misalignment resulting in aneuploidy in mouse embryonic fibroblasts

• however, lagging chromosomes and chromatin bridges are not observed

neoplasm

neoplasm ( J:195237 )

N • mice are not tumor prone (spontaneous or DMBA-induced)

endocrine/exocrine glands

small seminiferous tubules ( J:195237 )

♂

small testis ( J:195237 )

♂

decreased testis weight ( J:195237 )

♂