hematopoietic system
N |
• mice exhibit normal red cell volumes, red blood cell count, hemoglobin and mean platelet volume
|
• mice without MPD exhibit increased granulocyte-macrophage progenitors compared with wild-type mice
|
• in mice with myeloproliferative disease
|
• in mice with myeloproliferative disease
|
• some mice exhibit myeloproliferative disease (MPD) features
• mice without MPD exhibit still myeloid expansion
|
• in mice with myeloproliferative disease with megakaryocyte infiltration
|
• the bone marrow of mice without MPD exhibits expansion of myeloid compartment with an increase in HSPC and progenitor cells compared with wild-type mice
• mice with or without MPD exhibit age-dependent compromised cobblestone area formation compared with wild-type cells
|
• increased colony forming units from the bone marrow of mice with MPD
• increased progenitor cells in the bone marrow of mice without MPD
|
• in some mice late in life
|
• in some mice at various stages
|
• mature granulocytes in in the blood and bone marrow of mice with myeloproliferative disease
|
• in the peripheral blood of mice without MPD after age 17 to 18 months
|
• in the bone marrow of mice without MPD
|
• mice with myeloproliferative disease exhibit effacement of follicle structure in the spleen
|
immune system
• mice without MPD exhibit increased granulocyte-macrophage progenitors compared with wild-type mice
|
• in mice with myeloproliferative disease
|
• in mice with myeloproliferative disease
|
• some mice exhibit myeloproliferative disease (MPD) features
• mice without MPD exhibit still myeloid expansion
|
• in some mice at various stages
|
• mature granulocytes in in the blood and bone marrow of mice with myeloproliferative disease
|
• in the peripheral blood of mice without MPD after age 17 to 18 months
|
• mice with myeloproliferative disease exhibit effacement of follicle structure in the spleen
|
cellular
• mice without MPD exhibit increased granulocyte-macrophage progenitors compared with wild-type mice
|
neoplasm
growth/size/body
• in mice with myeloproliferative disease
|
• in mice with myeloproliferative disease
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | acute myeloid leukemia | DOID:9119 |
OMIM:601626 |
J:194999 |