Phenotypes Associated with This Genotype

Genotype
MGI:5485067

hm1

• Allelic Composition: Ifit2^tm1.1Gcs/Ifit2^tm1.1Gcs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:195382 )

• all mice infected with vesicular stomatitis virus (VSV) die within 7 days compared with 21% of wild-type mice at 7 to 10 days

• however, mice exhibit normal mortality following infection with encephalomyocarditis virus (EMCV) and are as susceptible as wild-type mice to intracranial VSV infection

immune system

increased susceptibility to Riboviria infection ( J:195382 )

• within 24 hours of vesicular stomatitis virus (VSV), mice develop neurological signs including ataxia, hind limb paralysis and hyper-excitability and increased brain viral titer due to enhanced viral replication compared with wild-type mice

• however, mice exhibit normal VSV entry into the olfactory bulb and other organs are normally susceptible to VSV infection

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:195382 )

• all mice infected with vesicular stomatitis virus (VSV) die within 7 days compared with 21% of wild-type mice at 7 to 10 days

• however, mice exhibit normal mortality following infection with encephalomyocarditis virus (EMCV) and are as susceptible as wild-type mice to intracranial VSV infection

behavior/neurological

ataxia ( J:195382 )

• in mice infected with vesicular stomatitis virus (VSV)

induced hyperactivity ( J:195382 )

• hyper-excitability in mice infected with vesicular stomatitis virus (VSV)

hindlimb paralysis ( J:195382 )

• in mice infected with vesicular stomatitis virus (VSV)