Phenotypes for Ptk2 Tg(MMTV-PyVT)634Mul MGI:5485071 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ptk2^tm3.1Guan/Ptk2^tm3.1Guan Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptk2^tm3.1Guan mutation (1 available); any Ptk2 mutation (91 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Suppressed mammary tumor growth in Ptk2^tm3.1Guan/Ptk2^tm3.1Guan Tg(MMTV-PyVT)634Mul/0 mice

neoplasm

decreased metastatic potential ( J:195658 )

• fewer metastatic nodules than in Ptk2^tm3.1Guan/Ptk2⁺ Tg(MMTV-PyVT)634Mul mice

abnormal tumor morphology ( J:195658 )

• tumor cells exhibit defective epithelial-mesenchymal transition and fewer mammary cancer stem cells compared to in Ptk2^tm3.1Guan/Ptk2⁺ Tg(MMTV-PyVT)634Mul mice

decreased tumor growth/size ( J:195658 )

• tumors grow slower than in Ptk2^tm3.1Guan/Ptk2⁺ Tg(MMTV-PyVT)634Mul mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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