Phenotypes for Col1a1 Gt(ROSA)26Sor MGI:5485198 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Col1a1^{tm1(tetO-EWSR1/ATF1)Yasu}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(tetO-EWSR1/ATF1)Yasu} mutation (0 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:194505 )

• after 3 to 10 months of doxycycline-treated mice with median survival of 20 weeks

neoplasm

tumor regression ( J:194505 )

• in doxycycline-treated mice following withdrawal of doxycycline

increased sarcoma incidence ( J:194505 )

• in the trunks, heads, limbs, and whisker pads of all doxycycline-treated mice after 3 months arising from neural crest-lineage cells

cellular

decreased fibroblast proliferation ( J:194505 )

• in doxycycline-treated mouse embryonic fibroblasts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
clear cell sarcoma		DOID:4233		J:194505

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13