About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5485272
Allelic
Composition
Tg(Myh6-tTA)6Smbf/0
Tg(tetO-Spp1)5Gad/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-tTA)6Smbf mutation (4 available)
Tg(tetO-Spp1)5Gad mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants show a large increase in mortality occurring between the 8th and 15th week after birth, with a half-life of 12 weeks

cardiovascular system
• cellular organization in hearts is altered after 11 weeks of age, with evidence of myocyte loss and interstitial cell infiltratio
• the number of apoptotic cells in the hear is increased at 11 weeks of age
• at 11 weeks of age, but not 6 weeks, heart left ventricle is severely dilated
• at 11 weeks of age, the left ventricle free wall is thinner during systole than in controls, suggesting the development of a hypokinetic dilated cardiomyopathy
• mutants exhibit systolic dysfunction at 11 weeks of age, indicated by reduced left ventricle fractional shortening
• ECG intervals during the last ECG recording before death show differences in PQ, QRS, QT, and QTc but not of RR
• mice that survive exhibit ECG parameters with normal values, with a moderate prolongation of PQ and QRS intervals
• mice that die during the 15th week, show complete atrioventricular block, with dissociation between the sinus and idioventricular escape rhythms
• at 11 weeks of age
• at 11 weeks of age, mutants show a moderately prolonged QRS interval
• at 11 weeks of age, ECGs show an abnormal repolarization with disappearance of the early positive phase of the T wave commonly seen in controls
• at 11 weeks of age, the T-wave duration is prolonged
• however, the QT interval is not prolonged
• hearts are infiltrated by a large number of interstitial cells; about 50% of infiltrating cells express panleukocyte CD45 marker

immune system
• hearts are infiltrated by a large number of interstitial cells; about 50% of infiltrating cells express panleukocyte CD45 marker

muscle
• at 11 weeks of age, the left ventricle free wall is thinner during systole than in controls, suggesting the development of a hypokinetic dilated cardiomyopathy
• mutants exhibit systolic dysfunction at 11 weeks of age, indicated by reduced left ventricle fractional shortening

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:194810


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory