Phenotypes Associated with This Genotype

Genotype
MGI:5486042

hm1

• Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex}
• Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:194928 )

• in mice fed a high fat diet

increased core body temperature ( J:194928 )

• in mice fed standard chow at room temperature of following cold exposure

increased oxygen consumption ( J:194928 )

• in fed mice on a high fat diet

abnormal glucose homeostasis ( J:194928 )

decreased circulating glucose level ( J:194928 )

• in fasting mice fed a high fat diet

improved glucose tolerance ( J:194928 )

• in mice fed a high fat diet

increased insulin sensitivity ( J:194928 )

• in mice fed a high fat diet

abnormal hormone level ( J:194928 )

abnormal circulating hormone level ( J:194928 )

decreased circulating insulin level ( J:194928 )

• in mice fed a high fat diet

decreased circulating leptin level ( J:194928 )

• in mice fed a high fat diet

increased adiponectin level ( J:194928 )

• in fed mice on a high fat diet

abnormal lipid homeostasis ( J:194928 )

decreased circulating cholesterol level ( J:194928 )

• in fed or fasted mice on a high fat diet

decreased liver triglyceride level ( J:194928 )

• in fed mice on a high fat diet

enhanced lipolysis ( J:194928 )

• stimulated by isoproterenol in mice fed a low or high fat diet

• however, serum fatty acid levels are normal

adipose tissue

decreased subcutaneous adipose tissue amount ( J:194928 )

• in mice fed a high fat diet

decreased brown adipose tissue mass ( J:194928 )

• in mice fed a high fat diet

increased brown fat cell number ( J:194928 )

• in mice on a high fat diet

decreased brown fat cell size ( J:194928 )

• in mice fed a high fat diet

decreased white fat cell size ( J:194928 )

• in mice fed a high fat diet with a lower frequency of midsized and large adipocytes in epididymal white adipose tissue

decreased epididymal fat pad weight ( J:194928 )

• in mice fed a high fat diet

decreased percent body fat/body weight ( J:194928 )

• in mice fed a low or high fat diet

growth/size/body

increased lean body mass ( J:194928 )

• in mice fed a low fat diet

decreased body weight ( J:194928 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced obesity ( J:194928 )

• in mice fed a high fat diet

liver/biliary system

decreased liver triglyceride level ( J:194928 )

• in fed mice on a high fat diet

decreased liver weight ( J:194928 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:194928 )

• in mice fed a high fat diet with smaller lipid-containing vacuoles

immune system

abnormal macrophage physiology ( J:194928 )

• impaired macrophage infiltration of adipose tissue in mice fed a high fat diet

integument

decreased subcutaneous adipose tissue amount ( J:194928 )

• in mice fed a high fat diet

hematopoietic system

abnormal macrophage physiology ( J:194928 )

• impaired macrophage infiltration of adipose tissue in mice fed a high fat diet