Phenotypes Associated with This Genotype

Genotype
MGI:5486142

• Allelic Composition: Tg(Camk2a-DISC1)37Asaw/0
• Genetic Background: C57BL/6-Tg(Camk2a-DISC1)37Asaw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain ventricle morphology ( J:124683 )

♂ • at 6 weeks, the lateral ventricles are enlarged in volume

♂ • at 6 weeks, the normal asymmetry between the left and right lateral ventricles is lost or even reversed

♂ • T2-weighted right value for the thalamus is increased compared to in wild-type mice

abnormal striatum morphology ( J:194985 )

• increase in the levels of dopamine D2 receptor in the striatum

• dopamine transporter is increased in the striatum

abnormal frontal lobe morphology ( J:124683 )

• a significant, but modest, reduction in parvalbumin, but not calbindin, immunoreactivity in the medial prefrontal cortex at 3 months of age, indicating abnormal neural synchrony in this region

decreased prepulse inhibition ( J:124683 )

♂ • when prepulse is 74 dB, prepulse inhibition is reduced compared to in wild-type mice

behavior/neurological

abnormal behavior ( J:124683 )

♂ • mice take longer to find hidden food pellets

♂ • however, mice do not display anxiety-associated behaviors, and exhibit normal spatial learning and memory in the Morris water maze, working memory in a Y-maze, and social interactions

enhanced behavioral response to addictive substance ( J:194985 )

• mutants exhibit increased sensitivity to metamphetamine, showing a greater augmentation in locomotion compared to wild-type littermates

impaired swimming ( J:124683 )

♂ • mice exhibit immobility when forced to swim

hyperactivity ( J:124683 )

♂ • mice places in an open field for 2 hours exhibit hyperactivity predominantly in the second hour

homeostasis/metabolism

decreased dopamine level ( J:194985 )

• baseline extracellular dopamine is decreased in the ventral striatum

increased physiological sensitivity to xenobiotic ( J:194985 )

• mutants exhibit increased sensitivity to metamphetamine, showing a higher increase in extracellular dopamine in the ventral striatum compared to wild-type littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:124683 , J:194985