Phenotypes Associated with This Genotype

Genotype
MGI:5487277

• Allelic Composition: Cacna1a^tm3Maag/Cacna1a^tm3Maag
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:193793 )

• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization and more frequent peri-infarct depolarizations after filament occlusion of the middle cerebral artery associated with rapid expansion of infarct core on diffusion-weighted magnetic resonance imaging and larger perfusion defects on laser speckle flowmetry

• mutants develop larger areas of cerebral blood flow deficit during distal middle cerebral artery occlusion due to increased susceptibility to ischemic depolarizations

• mutant cortical tissue requires a higher cerebral blood flow threshold level for survival compared to wild-type mice

increased cerebral infarct size ( J:193793 )

• transient filament occlusion of the middle cerebral artery for 1 hour produces larger infarcts than in wild-type mice, with more severe cortical, hippocampal, and thalamic involvement

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:193793 )

• mortality rate following filament occlusion of the middle cerebral artery is higher in mutants, reaching 100% within 24 hours after stroke onset

nervous system

increased susceptibility to ischemic brain injury ( J:193793 )

• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization and more frequent peri-infarct depolarizations after filament occlusion of the middle cerebral artery associated with rapid expansion of infarct core on diffusion-weighted magnetic resonance imaging and larger perfusion defects on laser speckle flowmetry

• mutants develop larger areas of cerebral blood flow deficit during distal middle cerebral artery occlusion due to increased susceptibility to ischemic depolarizations

• mutant cortical tissue requires a higher cerebral blood flow threshold level for survival compared to wild-type mice

increased cerebral infarct size ( J:193793 )

• transient filament occlusion of the middle cerebral artery for 1 hour produces larger infarcts than in wild-type mice, with more severe cortical, hippocampal, and thalamic involvement

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial hemiplegic migraine		DOID:0060178		J:193793