Phenotypes Associated with This Genotype

Genotype
MGI:5487278

• Allelic Composition: Cacna1a^tm3Maag/Cacna1a⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:193793 )

• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization after filament occlusion of the middle cerebral artery

increased cerebral infarct size ( J:193793 )

• transient filament occlusion of the middle cerebral artery for 30 minutes produces larger infarcts than in wild-type mice

• females show more striking increases in infarct volume than males

• treatment with the NMDA antagonist MK-801 significantly reduces infarct volume by 45% in mutants compared with only 23% in wild-type mice

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:193793 )

♀ • females exhibit more than 60% mortality between 24 and 96 hours following transient filament occlusion of the cerebral artery for 30 minutes

nervous system

increased susceptibility to ischemic brain injury ( J:193793 )

• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization after filament occlusion of the middle cerebral artery

increased cerebral infarct size ( J:193793 )

• transient filament occlusion of the middle cerebral artery for 30 minutes produces larger infarcts than in wild-type mice

• females show more striking increases in infarct volume than males

• treatment with the NMDA antagonist MK-801 significantly reduces infarct volume by 45% in mutants compared with only 23% in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial hemiplegic migraine		DOID:0060178		J:193793