Phenotypes Associated with This Genotype

Genotype
MGI:5488510

• Allelic Composition: Tg(Tlr7)1Boll/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:127600 )

• higher incidence at an early age compared to lines with lower levers of expression (Tg(Tlr7)6Boll)

immune system

abnormal dendritic cell morphology ( J:127600 )

• greater than 10% CD11c+ cells in the blood of all mice

• cells have elevated amounts of molecules indicative of enhanced activation

abnormal spleen morphology ( J:127600 )

enlarged spleen ( J:127600 )

• severe and seen as early as 2 months of age

• spleens can weigh as much as 30 times more than spleens from wild-type controls in morbid mice

• detected in 6 of 6 mice

decreased spleen white pulp amount ( J:127600 )

• white pulps are severely atrophied in morbid mice

abnormal circulating chemokine level ( J:127600 )

• highly elevated MCP-1 levels

increased circulating interleukin-6 level ( J:127600 )

• highly elevated

increased circulating tumor necrosis factor level ( J:127600 )

• highly elevated

autoimmune response ( J:127600 )

• autoantibodies show a nuclear or mixed pattern

increased anti-nuclear antigen antibody level ( J:127600 )

• increase in anti-RNA IgG levels in 5 of 7 mice

liver inflammation ( J:127600 )

• detected in 5 of 6 mice

glomerulonephritis ( J:127600 )

• detected in 3 of 6 mice

homeostasis/metabolism

abnormal circulating chemokine level ( J:127600 )

• highly elevated MCP-1 levels

increased circulating interleukin-6 level ( J:127600 )

• highly elevated

increased circulating tumor necrosis factor level ( J:127600 )

• highly elevated

renal/urinary system

glomerulonephritis ( J:127600 )

• detected in 3 of 6 mice

liver/biliary system

liver inflammation ( J:127600 )

• detected in 5 of 6 mice

hematopoietic system

extramedullary hematopoiesis ( J:127600 )

• signs of compensatory erythropoiesis with expansion of erythroblasts in the spleens of anemic mice

anemia ( J:127600 )

• severe

thrombocytopenia ( J:127600 )

• severe

abnormal dendritic cell morphology ( J:127600 )

• greater than 10% CD11c+ cells in the blood of all mice

• cells have elevated amounts of molecules indicative of enhanced activation

abnormal spleen morphology ( J:127600 )

enlarged spleen ( J:127600 )

• severe and seen as early as 2 months of age

• spleens can weigh as much as 30 times more than spleens from wild-type controls in morbid mice

• detected in 6 of 6 mice

decreased spleen white pulp amount ( J:127600 )

• white pulps are severely atrophied in morbid mice

growth/size/body

enlarged spleen ( J:127600 )

• severe and seen as early as 2 months of age

• spleens can weigh as much as 30 times more than spleens from wild-type controls in morbid mice

• detected in 6 of 6 mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:193610