Phenotypes for Gja8 MGI:5489760 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gja8^R205G/Gja8^R205G
Genetic Background	B6.Cg-Gja8^R205G

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dense nuclear cataracts in Gja8^R205G/Gja8^R205G and Gja8^R205G/Gja8^R205G Gja3^tm1Scr/Gja3^tm1Scr mice but degenerating peripheral lens fibers only in Gja8^R205G/Gja8^R205G mice

vision/eye

lens vacuoles ( J:195727 )

• aberrant vacuole-like structures in the lens periphery

nuclear cataract ( J:195727 )

• dense

small lens ( J:195727 )

microphthalmia ( J:195727 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 1 multiple types		DOID:0110231	OMIM:116200	J:195727

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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