Phenotypes Associated with This Genotype

Genotype
MGI:5490615

hm5

• Allelic Composition: Dmd^mdx/Dmd^mdx
• Genetic Background: involves: BALB/c * C57BL/10ScSn * C57BL/Ka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired exercise endurance ( J:125527 )

• mice exhibit a shorter time to exhaustion than wild type controls

• lower endurance on treadmill than Prkdc^scid Dmd^mdx double mutants

increased transforming growth factor beta level ( J:125527 )

• costal diaphragm (DIA) has higher quantity of active TGFB1 in comparison to Prkdc^scid Dmd^mdx double mutants although total quantity is similar

• tibialis anterior (TA) and quadricepts (QA) muscles have a higher content of total TGB1 in comparison to Prkdc^scid Dmd^mdx double mutants

muscle

increased skeletal muscle fiber diameter ( J:125527 )

• area of muscle fibers is 1500-1700 um² and coefficient of variance is 55-65

centrally nucleated skeletal muscle fibers ( J:125527 )

• small, centrally nucleated, regenerating muscle fibers are found in 2 and 12 month old mice

• 40-45% of muscle fibers exhibit centrally located nuclei

skeletal muscle fiber degeneration ( J:125527 )

• degenerating muscle fibers are found in 2 and 12 month old mice

skeletal muscle fibrosis ( J:125527 )

• high rate of fibrosis is observed in aged 12 month old mice

impaired skeletal muscle contractility ( J:125527 )

• loss of normalized tetanic force is observed in 2 and 12 month old mice

skeleton

abnormal vertebral column morphology ( J:125527 )

• progressive spinal deformity

behavior/neurological

impaired exercise endurance ( J:125527 )

• mice exhibit a shorter time to exhaustion than wild type controls

• lower endurance on treadmill than Prkdc^scid Dmd^mdx double mutants