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Phenotypes Associated with This Genotype
Genotype
MGI:5491050
Allelic
Composition		 Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*P101L)2866Sbp/Tg(Prnp*P101L)2866Sbp
Genetic
Background		 involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (37 available); any Prnp mutation (142 available)
Tg(Prnp*P101L)2866Sbp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:136434 )
• mean age for development of neurologic disease is 85 +/- 2 days

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Gerstmann-Straussler-Scheinker syndrome DOID:4249 OMIM:137440
 J:136434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory