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Phenotypes Associated with This Genotype
Genotype
MGI:5495281
cn1
Allelic
Composition		 Wnt1tm1.1Mze/Wnt1tm1.1Mze
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Wnt1-cre/ERT)1Alj/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (1027 available)
Tg(Wnt1-cre/ERT)1Alj mutation (1 available)
Wnt1tm1.1Mze mutation (0 available); any Wnt1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal midbrain morphology ( J:194842 )
• following tamoxifen treatment at E8.5, the ventral mesencephalon is smaller and has an abnormal notch at E12.5
• depletion of TH+ neurons in the medial ventral mesencephalon and an increase in TH+ neurons in the off-midline plane in 2 of 4 embryos at E12.5
• tamoxifen treatment at E10.5 does not produce an overt phenotype in the mesencephalon

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory