Phenotypes Associated with This Genotype

Genotype
MGI:5496257

• Allelic Composition: Lrsam1^{Gt(RRK461)Byg}/Lrsam1^{Gt(RRK461)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon morphology ( J:196447 )

• number of axons in the motor branch of the femoral nerve is slightly reduced at >12 months of age compared to controls, although cross-sectional area of axons is unchanged

• average axon diameter in the sensory branch of the femoral nerve is slightly increased at >12 months of age compared to controls

• 5 month old mice treated with the neurotoxic agent acrylamide have reduced axon cross-sectional areas in the motor branch of the femoral nerve, suggesting a loss of large diameter axons

abnormal neuromuscular synapse morphology ( J:196447 )

• area of neuromuscular junction of the tibialis anterior muscle is increased at 5 months of age, but is similar to control at > 12 months of age

axon degeneration ( J:196447 )

• peripheral motor axons exhibit increased sensitivity to acrylamide-induced degeneration

• untreated mice exhibit modest differences in neuromuscular junction area and axon number

decreased nerve conduction velocity ( J:196447 )

• decrease in nerve conduction velocity is observed in 5 month old mice treated with the neurotoxic agent acrylamide for two weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease axonal type 2P		DOID:0110169	OMIM:614436	J:196447