Phenotypes Associated with This Genotype

Genotype
MGI:5496284

• Allelic Composition: Robo1^b2b872Clo/Robo1^b2b872Clo
• Genetic Background: C57BL/6J-Robo1^b2b872Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 872-004-LA exhibits dilated atria, with biventricular hypertrophy noted by histopathology

cardiovascular system

abnormal heart morphology ( J:244438 )

• newborns exhibit heart malformations

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

double outlet right ventricle ( J:175213 , J:244438 )

ostium secundum atrial septal defect ( J:244438 )

atrioventricular septal defect ( J:244438 )

ventricular septal defect ( J:175213 )

perimembraneous ventricular septal defect ( J:244438 )

muscular ventricular septal defect ( J:244438 )

craniofacial

abnormal craniofacial morphology ( J:244438 )

• newborns exhibit craniofacial anomalies

micrognathia ( J:175213 , J:244438 )

cleft palate ( J:175213 , J:244438 )

short snout ( J:244438 )

• newborns exhibit a shoretned snout

digestive/alimentary system

cleft palate ( J:175213 , J:244438 )

endocrine/exocrine glands

abnormal sex gland morphology ( J:175213 )

• abnormal gonad placement

renal/urinary system

abnormal kidney morphology ( J:175213 )

• multiple/duplex, cystic and dysplastic kidney

polycystic kidney ( J:175213 )

hydronephrosis ( J:175213 )

hydroureter ( J:175213 )

reproductive system

abnormal sex gland morphology ( J:175213 )

• abnormal gonad placement

skeleton

micrognathia ( J:175213 , J:244438 )

growth/size/body

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

cleft palate ( J:175213 , J:244438 )

short snout ( J:244438 )

• newborns exhibit a shoretned snout

polycystic kidney ( J:175213 )

muscle

heart left ventricle hypertrophy ( J:175213 )

heart right ventricle hypertrophy ( J:175213 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cystic kidney disease		DOID:2975		J:175213