Phenotypes Associated with This Genotype

Genotype
MGI:5496793

cn29

• Allelic Composition: Esrra^tm1.1Ics/Esrra^tm1.1Ics; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129S2/SvPas * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal trabecular bone morphology ( J:195925 )

♀ • ovariectomized female mice do not exhibit loss of bone volume, bone mineral density or trabecular thickness unlike control mice

♀ • however, orchidectomized male mice exhibit normal loss of bone volume and bone mineral density

abnormal skeleton physiology ( J:195925 )

♀ • ovariectomized female mice are protected from bone loss compared with control mice

♀ • however, age-induced bone loss is normal