Phenotypes Associated with This Genotype

Genotype
MGI:5499285

cx7

• Allelic Composition: Hdac6^tm1.1Pmt/Y; Tg(SOD1*G93A)1Gur/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:194977 )

♂ • modest increase in survival compared with Tg(SOD1*G93A)1Gur mice

nervous system

abnormal innervation pattern to muscle ( J:194977 )

♂ • NMJ innervation of the gastrocnemius muscle is improved compared to in Tg(SOD1*G93A)1Gur mice

increased neuron number ( J:194977 )

♂ • in the ventral horn compared to in Tg(SOD1*G93A)1Gur mice with more pronounced protection of large neurons

abnormal action potential ( J:194977 )

♂ • mice exhibit higher compound action potential amplitudes compared with Tg(SOD1*G93A)1Gur mice

behavior/neurological

decreased grip strength ( J:194977 )

♂ • same age of onset as in Tg(SOD1*G93A)1Gur mice