Phenotypes Associated with This Genotype

Genotype
MGI:5499736

• Allelic Composition: Myh9^{tm1.1(MYH9*)Mjk}/Myh9^{tm1.1(MYH9*)Mjk}
• Genetic Background: B6.129-Myh9^{tm1.1(MYH9*)Mjk}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal megakaryocyte morphology ( J:175367 )

• with neutrophil inclusions in the bone marrow

abnormal neutrophil morphology ( J:175367 )

• contain Myh9 aggregates

abnormal platelet morphology ( J:175367 )

• increased diameter

thrombocytopenia ( J:175367 )

• macrothrombocytopenia

homeostasis/metabolism

increased bleeding time ( J:175367 )

albuminuria ( J:175367 )

renal/urinary system

albuminuria ( J:175367 )

glomerulosclerosis ( J:175367 )

• focal segmental glomerulosclerosis and focal global glomerulosclerosis beginning at 4 months

immune system

abnormal neutrophil morphology ( J:175367 )

• contain Myh9 aggregates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
MYH-9 related disease		DOID:0060651	OMIM:155100	J:175367