Phenotypes Associated with This Genotype

Genotype
MGI:5499839

cx2

• Allelic Composition: Mecp2^tm1.1Bird/Y; Sqle^Sum3-Jus/Sqle⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:198551 )

• lifespan in increased at least 3 weeks from the average 50% lethality time point of Mecp2^tm1.1Bird hemizygotes

behavior/neurological

lethargy ( J:198551 )

• at 20 weeks but ameliorated compared to in Mecp2^tm1.1Bird hemizygotes

decreased startle reflex ( J:198551 )

• as in Mecp2^tm1.1Bird hemizygotes

limb grasping ( J:198551 )

• at 8 and 20 weeks but ameliorated compared to in Mecp2^tm1.1Bird hemizygotes

tremors ( J:198551 )

• at 8 and 20 weeks but ameliorated compared to in Mecp2^tm1.1Bird hemizygotes

impaired coordination ( J:198551 )

• ameliorated compared to in Mecp2^tm1.1Bird hemizygotes

abnormal locomotor activation ( J:198551 )

• ameliorated compared to in Mecp2^tm1.1Bird hemizygotes

craniofacial

malocclusion ( J:198551 )

• as in Mecp2^tm1.1Bird hemizygotes

growth/size/body

malocclusion ( J:198551 )

• as in Mecp2^tm1.1Bird hemizygotes

abnormal body weight ( J:198551 )

• at 8 and 20 weeks but ameliorated compared to in Mecp2^tm1.1Bird hemizygotes

immune system

dermatitis ( J:198551 )

• unlike Mecp2^tm1.1Bird hemizygotes

integument

dermatitis ( J:198551 )

• unlike Mecp2^tm1.1Bird hemizygotes

respiratory system

increased pulmonary respiratory rate ( J:198551 )

• as in Mecp2^tm1.1Bird hemizygotes

skeleton

malocclusion ( J:198551 )

• as in Mecp2^tm1.1Bird hemizygotes