Phenotypes Associated with This Genotype

Genotype
MGI:5500063

hm2

• Allelic Composition: Lin28a^tm1Egm/Lin28a^tm1Egm
• Genetic Background: involves: 129S/SvEv * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased germ cell number ( J:196313 )

• in neonates

decreased oocyte number ( J:196313 )

♀ • following hormone-induced superovulation

oligozoospermia ( J:196313 )

♂

decreased primordial germ cell number ( J:196313 )

• in genital ridges at E13.5

decreased primordial ovarian follicle number ( J:196313 )

♀ • however, the number of maturing follicles and corpora lutea are normal

decreased ovary weight ( J:196313 )

♀

reduced female fertility ( J:196313 )

♀

decreased litter size ( J:196313 )

• from female and male mice

• however, older male mice produce normal-sized litters

reduced male fertility ( J:196313 )

♂

growth/size/body

decreased body size ( J:196313 )

decreased body weight ( J:196313 )

homeostasis/metabolism

decreased circulating testosterone level ( J:196313 )

♂ • in older male mice

♂ • however, luteinizing hormone levels are normal

decreased circulating follicle stimulating hormone level ( J:196313 )

♂ • in male mice

behavior/neurological

decreased male mating frequency ( J:196313 )

♂ • in older male mice

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:196313 )

♀ • however, the number of maturing follicles and corpora lutea are normal

decreased ovary weight ( J:196313 )

♀

cellular

decreased germ cell number ( J:196313 )

• in neonates

decreased oocyte number ( J:196313 )

♀ • following hormone-induced superovulation

oligozoospermia ( J:196313 )

♂

decreased primordial germ cell number ( J:196313 )

• in genital ridges at E13.5