Phenotypes Associated with This Genotype

Genotype
MGI:5501186

cn5

• Allelic Composition: Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan; Tg(CAG-Bgeo/GFP)21Lbe/0; Tg(Neurog3-cre)C1Able/0
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:195153 )

• mice die within the first few days after birth

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:195153 )

N • mice do not exhibit endocrine-to-acinar fate conversion

N • beta cells exhibit normal cell proliferation and apoptosis

abnormal pancreatic beta cell differentiation ( J:195153 )

• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells

increased pancreatic alpha cell number ( J:195153 )

decreased pancreatic beta cell number ( J:195153 )

• due to reduced differentiation without an effect on proliferation and apoptosis

increased pancreatic delta cell number ( J:195153 )

increased pancreatic epsilon cell number ( J:195153 )

homeostasis/metabolism

hyperglycemia ( J:195153 )

dehydration ( J:195153 )

cellular

abnormal pancreatic beta cell differentiation ( J:195153 )

• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells