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Phenotypes Associated with This Genotype
Genotype
MGI:5501187
cn4
Allelic
Composition		 Nkx6-1tm1.1Msan/Nkx6-1+
Pdx1tm1Cvw/Pdx1+
Tg(Neurog3-cre)C1Able/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1tm1.1Msan mutation (1 available); any Nkx6-1 mutation (4 available)
Pdx1tm1Cvw mutation (1 available); any Pdx1 mutation (37 available)
Tg(Neurog3-cre)C1Able mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic islet morphology ( J:195153 )
• mice exhibit an increase in the glucagon to insulin cell ratio as in Pdx1tm1Cvw heterozygotes
increased pancreatic alpha cell number ( J:195153 )
• as in Pdx1tm1Cvw heterozygotes
decreased pancreatic beta cell number ( J:195153 )
• as in Pdx1tm1Cvw heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory