mortality/aging
• mice die before late E12.5
|
embryo
• on mouse embryonic fibroblasts derived from E11.5 embryos
|
• randomized
|
• mice exhibit failure of somite derivatives, including putative ribs, to migrate and properly differentiate
|
cardiovascular system
• randomized and mislooped
|
• randomized and mislooped
|
respiratory system
homeostasis/metabolism
skeleton
absent ribs
(
J:171617
)
muscle
limbs/digits/tail
• in rare surviving, later-staged embryos
|
digestive/alimentary system
cellular
• on mouse embryonic fibroblasts derived from E11.5 embryos
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
short-rib thoracic dysplasia 7 with or without polydactyly | DOID:0110090 |
OMIM:614091 |
J:171617 |