Phenotypes Associated with This Genotype

Genotype
MGI:5502430

• Allelic Composition: Kras^tm1Bbd/Kras^tm1Bbd; Tg(Cela1-tTA)#Eps/?; Tg(tetO-cre)3Jig/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:119988 )

• focal morphological lesions develop in acinar and centroacinar cells at 1-3 months

• acinar to ductal metaplasias develop

• some mice develop ductal adenocarcinomas by 12 months

• properties are similar to those in human patients

• sometimes areas of non malignant hyperplasia develop

increased tumor latency ( J:119988 )

• latency is increased if gene expression is delayed by maintaining exposure to doxycycline until 10 days of age

• if doxycycline exposure continues to 2 months of age, no pancreatic abnormalities develop

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:119988 )

• focal morphological lesions develop in acinar and centroacinar cells at 1-3 months

• acinar to ductal metaplasias develop

• some mice develop ductal adenocarcinomas by 12 months

• properties are similar to those in human patients

• sometimes areas of non malignant hyperplasia develop

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:119988