Phenotypes Associated with This Genotype

Genotype
MGI:5502432

• Allelic Composition: Kras^tm1Bbd/Kras⁺; Trp53^tm1Brd/Trp53⁺; Tg(Cela1-tTA)#Eps/?; Tg(tetO-cre)3Jig/?
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:119988 )

• 50% mortality by 6 months of age

• 100% mortality by 1 year of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:119988 )

• all mice develop moderately to poorly differentiated pancreatic ductal adenocarcinomas, peritoneal explants, and perineural extensions

increased metastatic potential ( J:119988 )

• metastases develop affecting liver, diaphragm, lungs, lymph nodes, and spleen

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:119988 )

• all mice develop moderately to poorly differentiated pancreatic ductal adenocarcinomas, peritoneal explants, and perineural extensions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:119988