Phenotypes Associated with This Genotype

Genotype
MGI:5502570

cx1

• Allelic Composition: Col1a1^{tm1(tetO-CDKN2A)Ibp}/Col1a1⁺; Tg(KRT5-rtTA)#Glk/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

alopecia ( J:196969 )

abnormal hair follicle development ( J:196969 )

• dysfunctional hair follicle stem cells in doxycycline-treated mice due to blockage of proliferation

decreased hair follicle number ( J:196969 )

• noticeable after 10 days and pronounced by 6 weeks in doxycycline-treated mice

abnormal hair cycle ( J:196969 )

• bulge stem cells in doxycycline-treated mice fail to enter into the cell cycle and initiate anagen with follicles remaining in a telogen-like state unlike in control mice

• resilencing in doxycycline re-treated mice prevents hair follicle growth unlike in control mice

• however, withdrawal of doxycycline restores entry into anagen

thick epidermis ( J:196969 )

• in some doxycycline-treated mice

abnormal skin physiology ( J:196969 )

• after 2 days, doxycycline-treated mice exhibit decreased proliferation and increased apoptosis of basal epidermal cells compared with control mice

• after 1 week, mice exhibit hyperproliferation of basal cells that decreases after longer induction times and increased cellular replicative senescence compared with control mice

• however, apoptosis rates are normal after 1 week of induction and removal of doxycycline prevents further increases in senescence

cellular

early cellular replicative senescence ( J:196969 )

• after 1 week, doxycycline-treated mice exhibit increased cellular senescence in the epidermis compared with control mice

• however, removal of doxycycline prevents further increases in senescence and treatment with TPA does not increase senescence