Phenotypes Associated with This Genotype

Genotype
MGI:5502687

• Allelic Composition: Ar^tm1Verh/Y; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal adipose tissue amount ( J:196857 )

♂ • while males on a normal chow diet are not obese, they show reduced perigonadal fat weight but increased interscapular brown adipose tissue at 3 months age

♂ • however, body fat composition is no longer different by 6 months of age

♂ • on a high-fat diet, males gain equal weight compared with controls, however after 24 weeks, they have more visceral fat, with increases in omental and mesenteric fat pad weights

increased brown adipose tissue amount ( J:196857 )

♂ • on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age

♂ • however, white adipose tissue morphology in the perigonadal and subcutaneous depots are normal

decreased gonadal fat pad weight ( J:196857 )

♂ • on a normal chow diet, males have reduced perigonadal fat weight and proportion

increased mesenteric fat pad weight ( J:196857 )

♂ • after 24 weeks of a high-fat diet, males show an increase in mesenteric fat pad weight compared to controls

increased omental fat pad weight ( J:196857 )

♂ • after 24 weeks of a high-fat diet, males show an increase in omental fat pad weight compared to controls

increased interscapular fat pad weight ( J:196857 )

♂ • on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age

growth/size/body

decreased susceptibility to weight gain ( J:196857 )

♂ • on a normal chow diet, males gain less weight than controls at 3 months of age

homeostasis/metabolism

hyperglycemia ( J:196857 )

♂ • males are euglycemic at 3 months of age, however between 3 and 12 months of age, males are unable to sustain the normal increase in insulin secretory capacity, and they develop hyperglycemia

♂ • after 24 weeks on a high-fat diet, mutants have a poorer secretory response and become more hyperglycemic than controls

increased circulating insulin level ( J:196857 )

♂ • males are euglycemic but hyperinsulinemic both in the fasted state and during glucose tolerance testing at 3 months of age

increased circulating triglyceride level ( J:196857 )

♂ • 3 month old males have elevated plasma triglyceride levels but normal liver triglycerides

impaired glucose tolerance ( J:196857 )

♂ • males show age-related glucose intolerance

insulin resistance ( J:196857 )

♂ • insulin resistance in 3 month old males on a normal diet, as indicated by hyperinsulinemia both in the fasted state and during glucose tolerance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:196857