Phenotypes Associated with This Genotype

Genotype
MGI:5504374

hm1

• Allelic Composition: Nf2^tm2Gvn/Nf2^tm2Gvn
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon morphology ( J:197562 )

• axons exhibit smaller diameters, shrinkage and reduced interfilament distances compared to in wild-type mice

• sciatic nerve axons exhibit misshapen and dysmorphic axons and accumulation of neurofilaments and mitochondria compared with wild-type sciatic nerves

• however, the total number of axons and overall axon caliber

abnormal action potential ( J:197562 )

• reduced compound muscle action potential amplitudes compared with wild-type mice

• however, nerve conduction velocities are normal

behavior/neurological

impaired coordination ( J:197562 )

• reduced latency to fall from a rotarod

increased thermal nociceptive threshold ( J:197562 )

• in a hot plate test