Phenotypes Associated with This Genotype

Genotype
MGI:5505260

hm1

• Allelic Composition: Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: HEPD0529_1_C05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N • mice exhibit normal life expectancy

cellular

decreased sensitivity to induced cell death ( J:197809 )

• mouse embryonic fibroblasts are resistant to 5-hydroxymethyluridine toxicity compared with wild-type cells

abnormal base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells