Phenotypes Associated with This Genotype

Genotype
MGI:5505784

• Allelic Composition: a/a; Rab27a^ash/Rab27a^ash
• Genetic Background: involves: C3H/HeSnJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:77395 )

N • Background Sensitivity: platelet-dense granules and platelet coagulation are normal or near normal unlike on the C3H/HeSnJ background

N • Background Sensitivity: concentrations of adenine nucleotides, ADP and ATP, of platelets are only nominally lower than controls and are not significantly different from controls compared to on the C3H/HeSnJ background where levels are depressed

decreased platelet serotonin level ( J:77395 )

• Background Sensitivity: platelet-dense granule serotonin levels are somewhat depressed in platelets compared to wild-type, but levels are much greater than on the C3H/HeSnJ background

homeostasis/metabolism

decreased platelet serotonin level ( J:77395 )

• Background Sensitivity: platelet-dense granule serotonin levels are somewhat depressed in platelets compared to wild-type, but levels are much greater than on the C3H/HeSnJ background

increased bleeding time ( J:77395 )

• Background Sensitivity: modest increase in bleeding time to 6.9 minutes from the normal 2.7 minutes, but shorter than on the C3H/HeSnJ background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Griscelli syndrome type 2		DOID:0060833	OMIM:607624	J:77395