Phenotypes Associated with This Genotype

Genotype
MGI:5506526

cx7

• Allelic Composition: Etv1^tm1Tmj/Etv1^tm1Tmj; Etv4^tm1Arbr/Etv4⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased muscle spindle number ( J:197913 )

• hypaxial (body wall and intercostal) muscles lack Etv4-positive muscle spindles while axial muscles have 14% of muscle spindles relative to control; hindlimb muscles retain about 50% of Etv4-positive muscle spindles

decreased sensory neuron number ( J:197913 )

• hypaxial (body wall and intercostal) muscles lack vGlut1 (Slc17a7)-positive spindle-associated sensory endings (SSEs) at P0-3 while axial muscles retain about 3%; hindlimb muscles retain about 50% of Slc17a7-positive SSEs

abnormal proprioceptive neuron morphology ( J:197913 )

• significant muscle to muscle variation in proprioceptive sensory neuron innervation is observed

muscle

decreased muscle spindle number ( J:197913 )

• hypaxial (body wall and intercostal) muscles lack Etv4-positive muscle spindles while axial muscles have 14% of muscle spindles relative to control; hindlimb muscles retain about 50% of Etv4-positive muscle spindles