Phenotypes Associated with This Genotype

Genotype
MGI:5506633

hm1

• Allelic Composition: Hfm1^{Gt(OST347241)Lex}/Hfm1^{Gt(OST347241)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal reproductive system morphology ( J:195265 )

abnormal ovary morphology ( J:195265 )

♀

decreased corpora lutea number ( J:195265 )

♀

abnormal ovarian follicle number ( J:195265 )

♀ • decreased number of ovarian follicles

small ovary ( J:195265 )

♀ • reduced size at 45 days of age but increased number of stromal cells

abnormal testis morphology ( J:195265 )

♂

abnormal seminiferous tubule morphology ( J:195265 )

♂ • normal number of seminiferous tubules but diameter of tubules is 30-50% of normal

small testis ( J:195265 )

♂ • reduced testis size

testis hypoplasia ( J:195265 )

♂ • testicular hypoplasia but hyperplasia of interstitial cells

abnormal gametogenesis ( J:195265 )

abnormal meiosis ( J:195265 )

abnormal chiasmata formation ( J:195265 )

• few chiasmata found

abnormal chromosomal synapsis ( J:195265 )

• prophase I checkpoint is not triggered

• fail to form stable divalents in normal numbers

abnormal meiotic configurations ( J:195265 )

• chromosomes often fail to form a metaphase plate

abnormal synaptonemal complex ( J:195265 )

• autosomal pairing is normal but defects in synapsis

• double strand breaks form normally but repair may be delayed or inefficient as inferred from persistent RAD51 foci

abnormal oogenesis ( J:195265 )

♀ • blocked

abnormal spermatogenesis ( J:195265 )

♂ • blocked

abnormal X-Y chromosome synapsis during male meiosis ( J:195265 )

♂ • normal X-Y pairing but defects in synapsis

arrest of male meiosis ( J:195265 )

♂ • block at diakinesis of meiosis I

♂ • apoptosis is common in spermatocytes at that point

infertility ( J:195265 )

female infertility ( J:195265 )

♀

male infertility ( J:195265 )

♂

endocrine/exocrine glands

abnormal ovary morphology ( J:195265 )

♀

decreased corpora lutea number ( J:195265 )

♀

abnormal ovarian follicle number ( J:195265 )

♀ • decreased number of ovarian follicles

small ovary ( J:195265 )

♀ • reduced size at 45 days of age but increased number of stromal cells

abnormal testis morphology ( J:195265 )

♂

abnormal seminiferous tubule morphology ( J:195265 )

♂ • normal number of seminiferous tubules but diameter of tubules is 30-50% of normal

small testis ( J:195265 )

♂ • reduced testis size

testis hypoplasia ( J:195265 )

♂ • testicular hypoplasia but hyperplasia of interstitial cells

cellular

abnormal meiosis ( J:195265 )

abnormal chiasmata formation ( J:195265 )

• few chiasmata found

abnormal chromosomal synapsis ( J:195265 )

• prophase I checkpoint is not triggered

• fail to form stable divalents in normal numbers

abnormal X-Y chromosome synapsis during male meiosis ( J:195265 )

♂ • normal X-Y pairing but defects in synapsis

arrest of male meiosis ( J:195265 )

♂ • block at diakinesis of meiosis I

♂ • apoptosis is common in spermatocytes at that point

abnormal meiotic configurations ( J:195265 )

• chromosomes often fail to form a metaphase plate

abnormal synaptonemal complex ( J:195265 )

• autosomal pairing is normal but defects in synapsis

• double strand breaks form normally but repair may be delayed or inefficient as inferred from persistent RAD51 foci

abnormal oogenesis ( J:195265 )

♀ • blocked