Phenotypes Associated with This Genotype

Genotype
MGI:5507885

cx5

• Allelic Composition: Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}; Ung^tm1Tld/Ung^tm1Tld
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
• Cell Lines: HEPD0529_1_B07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N • mice exhibit normal life expectancy

cellular

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch