Phenotypes for Msh2 Smug1 Ung MGI:5507886 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_B07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Smug1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Smug1 mutation (14 available)
Ung^tm1Tld mutation (0 available); any Ung mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:197809 )

• mean life expectancy is 107 days compared with 223 days for Msh2^tm1Htr homozygotes

preweaning lethality, incomplete penetrance ( J:197809 )

• fewer than expected mice are identified at weaning

neoplasm

increased tumor incidence ( J:197809 )

• in all mice that die

increased lymphoma incidence ( J:197809 )

• in 4 of 5 mice with tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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