Phenotypes Associated with This Genotype

Genotype
MGI:5508218

• Allelic Composition: Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr; Ctnnb1^tm1Mmt/Ctnnb1⁺; Krt14^{tm1.1(cre)Wbm}/Krt14⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:199091 )

• mutants succumb to tumors rapidly, dying between P75 and P90

neoplasm

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

increased squamous cell carcinoma incidence ( J:199091 )

• tumors arise from the submandibular salivary glands and are classified as salivary gland squamous cell carcinoma

digestive/alimentary system

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

integument

increased hair follicle number ( J:199091 )

• excessive supernumerary hair follicles in the skin

craniofacial

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

growth/size/body

increased salivary gland tumor incidence ( J:199091 )

• rapidly develop aggressive tumors in the salivary glands

• tumors contain transplantable and hyperproliferative tumor propagating cells (CD24+CD29+)

• treatment of cultured CD24+CD29+ tumor cells with the canonical Wnt inhibitor ICG-001 blocks proliferation of these cells

• CD24+CD29+ tumor propagating cells from salivary gland tumors exhibit unrestricted self-renewal in salisphere culture

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
salivary gland carcinoma		DOID:0050904		J:199091